27-year-old Arata Kaizaki joins the ranks of the unemployed, after an incident causes him to quit his job after only five months. He meets a strange man named Ryo Yoake, who urges him to participate in a social reintegration program called “ReLIFE” that involves taking an experimental drug that will rejuvenate his appearance by 10 years for a period of one year. Thinking he has nothing to lose, Kaizaki reenters high school, where he gradually forms a strong bond with a unique group of classmates including Chizuru Hishiro. Kaizaki finds himself falling in love with Chizuru, but once the one-year experiment expires, he will be erased from her memory… What will become of their love? What future will Kaizaki choose to pursue after ReLIFE? The story will take a surprising and dramatic ending.